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VPAC1 Targeted 64Cu-TP3805 kit preparation and its evaluation

By August 28, 2017February 28th, 2021No Comments

Sushil K.Tripathia1 PardeepKumara Edouard J.Trabulsib SungKimaPeter A.McCuec CharlesIntenzoa AdamBergerd LeonardGomellabe Mathew L.Thakurae

Abstract

Introduction

Previously, our laboratory has shown that 64Cu-TP3805 can specifically target VPAC1 receptors and be used for positron emission tomography (PET) imaging of breast (BC) and prostate cancer (PC) in humans. Present work is aimed at the formulation of a freeze-dried diaminedithiol-peptide (N2S2-TP3805) kit and it’s evaluation for the preparation of 64Cu labeled TP3805. Parameters such as pH, temperature and incubation time were examined that influenced the radiolabeling efficiency and stability of the product.

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