This publication showed that VIP receptors are very important in the biology of many malignancies and are overexpressed in many tumors; thus, VIP receptors can be targeted by receptor-specific molecules. The generation of radiolabeled peptides has opened new avenues for the molecular imaging and therapy of tumors. They are becoming ideal candidates for molecular imaging techniques and therapeutic interventions.
Vasoactive intestinal peptide receptor-based imaging and treatment of tumors (Review)
1Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037; 2Department of Nuclear Medicine,
Referenced: Thakur ML, Marcus CS, Saeed S, Pallela V, Minami C, Diggles L, Le Pham H, Ahdoot R and Kalinowski EA: 99mTclabeled vasoactive intestinal peptide analog for rapid localization of tumors in humans
Thakur ML, Chakder S and Rattan S: 99mTc-labeled vasoactive intestinal peptide receptor agonist: functional studies.
Thakur ML, Marcus CS, Saeed S, Pallela V, Minami C, Diggles L, Pham HL, Ahdoot R, Kalinowski EA and Moody T: Imaging tumors in human