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February 28, 2021 in Publications

Evaluating Ga-68 Peptide Conjugates for Targeting VPAC Receptors: Stability and Pharmacokinetics

Pardeep Kumar  1 , Sushil K Tripathi  1 , C P Chen  2 , Eric Wickstrom  3   4 , Mathew L Thakur  5   6   7  …
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May 28, 2020 in Publications

VIP/PACAP, and their receptors and cancer

Abstract Purpose of review—To summarize the roles of VIP/PACAP and their receptors(VPAC1, VPAC2/PAC1) in human tumors as well as their role in potential novel treatments.…
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January 28, 2019 in Publications

Investigation into a novel, but simple, non-invasive approach for detection of genitourinary cancer.

Cancer remains one of the most formidable diseases of mankind. Genitourinary cancers, such as those involving prostate (CaP) and bladder urothelium, are common malignancies. However,…
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January 28, 2019 in Publications

Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase Activating Peptide Receptor 1 (VPAC1) Targeted Detection of Genitourinary Cancer: A Urinary Assay

Prostate cancer (CaP) and bladder urothelial cancer (BUC) are the two most common malignancies in urology, and both overexpress VPAC1. VPAC1 is overexpressed at the…
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August 28, 2017 in Publications

VPAC1 Targeted 64Cu-TP3805 kit preparation and its evaluation

Sushil K.Tripathia1 PardeepKumara Edouard J.Trabulsib SungKimaPeter A.McCuec CharlesIntenzoa AdamBergerd LeonardGomellabe Mathew L.Thakurae https://doi.org/10.1016/j.nucmedbio.2017.04.007Get rights and content Abstract Introduction Previously, our laboratory has shown that 64Cu-TP3805…
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August 28, 2017 in Publications

Development of a voided urine assay for detecting prostate cancer non-invasively: a pilot study

This publication has validated the Thomas Jefferson University hypothesis that prostate cancer can be detected non-invasively by a simple and reliable assay by targeting genomic VPAC…
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March 28, 2017 in Publications

VPAC1 Targeted 64Cu-TP3805 Positron Emission Tomography Imaging of Prostate Cancer: Preliminary Evaluation in Man

The feasibility study of 25 patients who underwent PET imaging, 212 prostate gland lesions had SUVmax > 1.0 vs 127 lesions identified by histology of…
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February 28, 2017 in Publications

PET Imaging of VPAC1 Expression in Experimental and Spontaneous Prostate Cancer

The primary screening methods for PC are prostate-specific antigen measurement and digital rectal examination (3). However, the reported sensitivity for digital rectal examination is only…
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March 28, 2013 in Publications

Vasoactive intestinal peptide receptor-based imaging and treatment of tumors (Review)

This publication showed that VIP receptors are very important in the biology of many malignancies and are overexpressed in many tumors; thus, VIP receptors can…
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February 28, 2013 in Publications

VPAC1 Receptors for Imaging Breast Cancer:A Feasibility Study

This feasibility study demonstrated the compelling need for an innovative approach that would decrease the number of unnecessary benign biopsies while still detecting the malignancies.…
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February 28, 2000 in Publications

99mTcLabeled Vasoactive Intestinal Peptide Analog for Rapid Localization of Tumors in Humans

In recent years, imaging tumors with receptor-specific biomolecules has been the focus of increasing interest. Vasoactive intestinal peptide (VIP)(VPAC) has a high affinity for specific…
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January 28, 2000 in Publications

Vasoactive Intestinal Peptide/Pituitary Adenylate Cyclase-activating Peptide Receptor Subtypes in Human Tumors and Their Tissues of Origin

The evaluation of peptide receptors in man is needed not only to discover the physiological target tissues of a given peptide but also to identify…
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